Fig. 5
From: Specific shifts in the endocannabinoid system in hibernating brown bears
Fold change in gene expression of target genes involved in endocannabinoids biosynthesis and catabolism in brown bear adipose tissue. Adipose tissues were collected from bears at both winter-hibernating and summer-active time points (Supplementary Table S1), total RNA was extracted and expression levels were measured by RT-qPCR. Data are normalized against TBP mRNA levels and expressed as a fold change relative to the summer condition, represented as mean ± SEM of separate extractions and quantifications (n = 5 for summer and n = 13 for winter samples). Unpaired Student t-test were used to compare wummer and winter data.* indicates p value < 0.05 when comparing seasons. CNR1: cannabinoid receptor 1, CNR2: cannabinoid receptor 2, DAGLA: diacylglycerol lipase alpha, DAGLB: diacylglycerol lipase beta, FAAH: fatty acid amide hydrolase, MGLL: monoacylglycerol lipase, NAPEPLD: N-acyl phosphatidylethanolamine phospholipase D, SBA: summer bear adipose tissue, WBA: winter bear adipose tissue